Protamine sulfate has an anticoagulanteffect, but if used in the proper amount, it counteractsthe action of heparin and is used as an antidote for thelatter in cases of overdosage. It is administered intravenouslyin a dose that depends on the circumstances.
Veterinary Drugs and Treatments
Protamine is used in all species for the treatment of heparin overdosage
when significant bleeding occurs. While protamine will neutralize
the anti-thrombin effects of low molecular weight heparins
(e.g., dalteparin or enoxaparin), it does not completely inhibit their
anti-Xa activity. Laboratory animal studies however, shows it does
improve microvascular bleeding associated with LMWH overdoses.
Protamine has been suggested for use for Bracken Fern toxicity in
ruminants (see Doses).
