4-(Methylthio)benzoic acid

Preparation of 4-methylthiobenzoic acid:

In a 10mL round-bottom flask, 0.77g of 4-methylthiobenzyl alcohol and 2g of diethylene glycol dimethyl ether were added sequentially. The resulting mixture was reacted in an ultrasonic reactor under open-air ultrasonic radiation at 40kHz/30W/70℃ for 30 minutes. The diethylene glycol dimethyl ether was removed under reduced pressure, and recrystallization yielded 0.79g of 4-methylthiobenzoic acid, with a yield of 95%.

An environmentally friendly method for synthesizing the benzoic acid compounds directly from 4-methylthiobenzyl alcohol as the starting material, using inexpensive, green, and safe air as the oxidant and inexpensive diethylene glycol dimethyl ether as the accelerator under solvent-free conditions.

Benzoic acid compounds, such as 4-methylthiobenzoic acid, are widely used in the chemical industry, including food, medicine, and dyes. They are also an important intermediate in organic synthesis.

light yellow to beige crystalline powder

Administration of 4-(methylthio)benzoic acid reduces cisplatin nephrotoxicity in rats. It prevents in vitro DNA binding and mutation induction in Escherichia coli K12.

Administration of 4-(methylthio)benzoic acid reduces cisplatin nephrotoxicity in rats. It prevents in vitro DNA binding and mutation induction in Escherichia coli K12.