2-Amino-3-bromobenzoic acid

20780-74-9

20776-51-6

The general procedure for the synthesis of 2-amino-3-bromobenzoic acid from 7-bromoindigo is as follows: commercially available 7-bromoindigo (18.0 g, 79.6 mmol) was dissolved in 5% aqueous sodium hydroxide solution (400 mL), and 30% aqueous hydrogen peroxide solution (22.5 mL, 199 mmol) was added slowly and dropwise at 50 °C. The reaction mixture was stirred continuously at 50 °C for 30 min. Subsequently, the reaction solution was cooled to room temperature and neutralized to neutral with 2.0 mol/L hydrochloric acid solution. The precipitated solid product was collected by filtration and dried under reduced pressure overnight to give the final target compound 2-amino-3-bromobenzoic acid.