B7-33 2mg/5mg/10mg

B7-33 is a selective relaxin receptor 1 (RXFP1) agonist. It binds to RXFP1 and preferentially activates thepERK pathway over cAMP in cells (with RXFP1 expression).

B7-33 is a single-chain relaxin mimetic. B7-33 is a selective relaxin receptor 1 (RXFP1) agonist. B7-33 binds to RXFP1 and preferentially activates thepERK pathway over cAMP in cells (with RXFP1 expression). B7-33 is an anti-fibrotic agent. B7-33 has cardioprotective effects[1][2].

[1] Alam F, et al. The single-chain relaxin mimetic, B7-33, maintains the cardioprotective effects of relaxin and more rapidly reduces left ventricular fibrosis compared to perindopril in an experimental model of cardiomyopathy. Biomed Pharmacother. 2023 Apr;160:114370. DOI:10.1016/j.biopha.2023.114370
[2] Hossain MA, et al. A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1. Chem Sci. 2016 Jun 1;7(6):3805-3819. DOI:10.1039/c5sc04754d