tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate

3934-20-1

57260-71-6

221050-88-0

General procedure for the synthesis of 2-chloro-4-(4-BOC-1-piperazinyl)pyrimidine from 2,4-dichloropyrimidine and N-BOC-piperazine: 2,4-dichloropyrimidine (2.0 g, 13.43 mmol) was accurately weighed and dissolved in N,N-dimethylformamide (DMF) (15 mL), followed by the addition of triethylamine (TEA) (2.72 g, 26.85 mmol) and 1-Boc piperazine (2.75 g, 14.77 mmol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction endpoint was confirmed by thin layer chromatography (TLC) monitoring. The reaction mixture was slowly poured into 200 mL of ice water, at which point a large amount of white solid precipitated. The white solid was collected by filtration and washed with an appropriate solvent and finally dried to afford the target product 2-chloro-4-(4-BOC-1-piperazinyl)pyrimidine (3.8 g, 13.43 mmol).