[2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol

Chemical Properties

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Animal Model:	Male C57BL/6J mice^[1]
Dosage:	10 mg/kg
Administration:	p.o., daily for 7 days
Result:	Decreased the efflux of DA, 5-HT and NE in mPFC, dSTR, HIP and NAC. Increased the efflux of DOPAC, HVA, and 5-HIAA in mPFC, dSTR, HIP and NAC. Decreased in cortical DA and DOPAC as well as striatal DA, 5-HT and NE efflux combinated with haloperidol (HY-14538, 0.5 mg/kg, i.p.). Decreased cortical Glu and striatal ACh, DA and GABA efflux combinated with Clozapine (HY-14539, 10 mg/kg, i.p.). Reduced PCP-induced increase in LMA between various time points. Suppressed clozapine-, olanzapine- and risperidone-induced DA efflux in both mPFC and dSTR, and ACh efflux in mPFC.