Coenzyme Q9 (Ubiquinone Q9) 是啮齿类动物泛醌的主要形式，是电子传递链中的一种双亲分子组分，具有内源性抗氧化剂的作用。Coenzyme Q9 可减轻糖尿病引起的抗氧化防御机制的下降。Coenzyme Q9 改善左心室功能，减少心肌梗死面积和心肌细胞凋亡。
Coenzyme Q9 (5 mg/kg; p.o.; once a day for 4 weeks) reduces myocardial ischemia/reperfusion injury.
CoQ
10
and CoQ
9
are components of themitochondrial respiratory chain in mammals and can regulate some mitochondrial proteins/functions. Soybean, corn, and rapeseed oils are very rich sources of CoQ
10
, whereas CoQ
9
has been found in high concentrations in corn oil.
The lack of a functional CoQ
9
protein in homozygous CoQ
9
mutant (CoQ
9
(X/X)) mice causes a severe reduction in the CoQ
7
protein and a widespread CoQ deficiency and accumulation of demethoxyubiquinone. The deficit in CoQ induces a brain-specific impairment of mitochondrial bioenergetics performance, a reduction in respiratory control ratio, ATP levels and ATP/ADP ratio and specific loss of respiratory complex I. These effects lead to neuronal death and demyelinization with severe vacuolization and astrogliosis in the brain of CoQ
9
(X/X) mice that consequently die between 3 and 6 months of age.
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Animal Model:
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Male Hartley guinea pigs of about 350-400 g body weight
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Dosage:
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5 mg/kg of body weight
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Administration:
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P.o.; once a day for 4 weeks
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Result:
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Nutritional supplementation of CoQ9 can reduce myocardial ischemia/reperfusion injury to the same extent as CoQ10.
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