ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT

Adenosine 5′-triphosphate, periodate oxidized sodium salt has been used:

• as an antagonist of the purinergic receptor, P2 × 7 to inhibit P2 × 7 pathway
• as a nonspecific agonist to assess the activity of P2×₇-R by the mobilization of Ca²⁺
• to evaluate the physiological significance of elevated intracellular ATP levels
• increased?P2rx7?expression for osteoclastogenesis in?Flcn-deficient cells

A 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X₇ purinergic receptors in J774 mouse macrophages. Does not affect P2_γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X₇ receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca²⁺ influx in lymphocytes (?100 μM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.

Reversible: no