Bromisovalum,Linhai Duqiao Fine
Chemical Factory
2-Bromo-3-methylbutyrylurea is a hypnotic and sedative drug marketed over the counter in Asian under various brand names.
ChEBI: An N-acylurea that is urea in which one of the hydrogens is replaced by a 2-bromo-3-methybutanoyl group.
A mixture of 2 kg 2-bromoisovalerylbromide and 1 kg dry urea is heated at
70°C. Then to the reaction mixture is added sodium hydrogen carbonate. 2-
Bromo-3-methylbutyrylurea is recrystallized from toluene or water, melting
point 149°C.
World Health Organization (WHO)
Bromisoval is a monureide sedative of long standing. It remains
available in several countries. However, it releases the bromide ion and prolonged
usage can result in chronic bromide accumulation and intoxication.
Moderately toxic by
ingestion. Human systemic effects by
ingestion: nausea or vomiting, and coma. A
sedative and hypnotic agent. When heated
to decomposition it emits very toxic fumes
of Brand NOx
Crystallise it from aqueous EtOH or toluene, and dry it in air. [Beilstein 3 H 63, 3 I 29, 3 II 51, 3 III 123, 3 IV 117.]
