Pramlintide

Antidiabetic.

This 37-residue pancreatic β-cell hormone (MW = 3.9 kDa; Sequence: KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY), also called Islet Amyloid Polypeptide (IAPP), is co-secreted with insulin and plays a role in glycemic regulation by retarding gastric emptying and promoting satiety. Amylin helps to prevent post-prandial spikes in blood glucose. Amylin potently inhibits (EC50 = 18 pM) amino acid-stimulated glucagon secretion. (Note: Human amylin is amyloidogenic, whereas the synthetic hormone known as Pramlintide (MW = 3951.41g; CAS 151126-32-8; Sequence: KCNTATCATQRLANFLVHSSNNFGPILPPTNVGSNTY-NH2; Tradename: Symlin) contains three prolyl residues that are found in Rat Amylin (Sequence: KCNTATCATQRLANFLVRSSNNLGPVLPPTNG SNTY) and is nonamyloidogenic.)

Store at -20°C

Pramlintide Synthetic is a single, non-glycosylated polypeptide chain containing 37 amino acids, having a molecular mass of 3949.4 Dalton and a Molecular formula of C₁₇₁H₂₆₇N₅₁O₅₃S₂.

Pramlintide acetate is a hormone that is released into the bloodstream, in a similar pattern as insulin. Pramlintide aids in the absorption of glucose by slowing gastric emptying, promoting satiety, and inhibiting inappropriate secretion of glucagon, a catabolic hormone that opposes the effects of insulin.