Enzyme inhibitor
This 37-residue pancreatic β-cell hormone (MW = 3.9 kDa; Sequence:
KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY), also called
Islet Amyloid Polypeptide (IAPP), is co-secreted with insulin and plays a
role in glycemic regulation by retarding gastric emptying and promoting
satiety. Amylin helps to prevent post-prandial spikes in blood glucose.
Amylin potently inhibits (EC50 = 18 pM) amino acid-stimulated glucagon
secretion. (Note: Human amylin is amyloidogenic, whereas the synthetic
hormone known as Pramlintide (MW = 3951.41g; CAS 151126-32-8;
Sequence: KCNTATCATQRLANFLVHSSNNFGPILPPTNVGSNTY-NH2;
Tradename: Symlin?) contains three prolyl residues that are found in Rat
Amylin (Sequence: KCNTATCATQRLANFLVRSSNNLGPVLPPTNG
SNTY) and is nonamyloidogenic.)
