Labelled analogue of Furamidine, a diphenylfuran compound belonging to an important class of antimicrobial and antiparasitic agents. Furamidine and its analogues also display antitumor activities and
showed antiproliferative activities against various tumor cell lines.
in vivo
Furamidine (1 mg/kg; intraperitoneal injection; 3 times a week and repeated every 4 weeks; for 34 weeks; female NZB/NZW mice) and Irinotecan combined treatment suppresses proteinuria and prolongs survival of lupus-prone NZB/NZW mice. The combination treatment does not change the levels of anti-dsDNA antibodies[3].
Animal Model:
Female NZB/NZW mice (6-week-old) with Irinotecan (1 mg/kg)[3]
Dosage:
1 mg/kg
Administration:
Intraperitoneal injection; 3 times a week and repeated every 4 weeks; for 34 weeks
Result:
Suppressed proteinuria and prolongs survival of lupus-prone NZB/NZW mice combined with Irinotecan.
