Egg oil (150-600 mg/kg, i.g. for 16 weeks) extracted from Portunus trituberculatus improves insulin sensibility and hepatic glycogen synthesis, alleviates insulin resistance through activation of PI3K/Akt/Glu4 signaling in skeletal muscle and PI3K/Akt/GSK3β/GS pathway in the liver[1].
Egg oil (150-600 mg/kg, i.g. for 16 weeks) extracted from Portunus trituberculatus amliorates HFD-induced obesity in mice, restores the gut microbial dysbiosis and down-regulates the LPS/TLR4 pathway in liver and epididymal adipose[3].
| Animal Model: | High-fat-diet feeding C57BL/6J mice[1][3] |
| Dosage: | 150-600 mg/kg |
| Administration: | i.g. for 16 weeks |
| Result: | Reduced body weight, adipose weight gain, blood glucose and lipids.
Increased mRNA levels of PI3K, Akt, IPS1/2, Glu4, GSK3β and GS i muscle and liver. |
