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Desonide

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Desonide Basic information
Desonide Chemical Properties
  • Melting point:272-274?C
  • Boiling point:580.1±50.0 °C(Predicted)
  • Density 1.30±0.1 g/cm3(Predicted)
  • storage temp. Refrigerator
  • pka12.87±0.10(Predicted)
  • CAS DataBase Reference638-94-8(CAS DataBase Reference)
Safety Information
  • HS Code 2937290000
  • ToxicityLD50 in rats (mg/kg): 93 s.c. (Phillips)
MSDS
Desonide Usage And Synthesis
  • Chemical PropertiesOff-White Solid
  • OriginatorTridesilon,Dome,US,1972
  • Usesantifungal
  • UsesAnti-inflammatory. Desonide has also been found as an impurity in budesonide (B689490).
  • DefinitionChEBI: Triamcinolone acetonide with hydrogen instead of the fluorine substituent at position 9. A corticosteroid anti-inflammatory, it is used topically as a cream, ointment or lotion for the treatment of various skin disorders.
  • IndicationsDesonide (DesOwen, Tridesilon) is a synthetic corticosteroid.
  • Manufacturing ProcessPreparation of 11β,21-Dihydroxy-16α,17α-Isopropylidenedioxy-1,4- Pregnadiene-3,20-Dione: A solution of 11β,16α,17α,21-tetrahydroxy-1,4- pregnadiene-3,20-dione (40 mg) in acetone (10 ml) containing hydrochloric acid (three drops; d 1.19) is boiled 3n the steam bath for two minutes and then allowed to stand for eighteen hours at room temperature. The reaction mixture is diluted with water (50 ml) and extracted with chloroform (3x25 ml), the combined extracts then being washed with water (30 ml) and dried over anhydrous sodium sulfate. The residue obtained by removal of solvent crystallized from ethyl acetate-petroleum ether as small plates (25 mg), melting point 257°-260°C.
  • brand nameDesowen (Galderma); Tridesilon (Perrigo).
  • Therapeutic FunctionAntiinflammatory
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