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METHSUXIMIDE

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METHSUXIMIDE Basic information
METHSUXIMIDE Chemical Properties
  • Melting point:52-53°
  • Boiling point:bp0.1 121-122°
  • Density 1.1255 (rough estimate)
  • refractive index 1.5440 (estimate)
  • storage temp. Refrigerator
  • Water Solubility 2.8g/L(25 ºC)
Safety Information
METHSUXIMIDE Usage And Synthesis
  • Chemical PropertiesLight Yellow Oil
  • OriginatorCelontin,Parke Davis,US,1957
  • UsesA calcium channel succinimide antiepileptic drug. Anticonvulsant.
  • Manufacturing Process100 g of α-phenyl-α-methylsuccinic acid and 110 g of 40% aqueous methyl amine are heated together at 200 to 250°C until no more distillate is obtained. Upon vacuum distillation of the residue, the N-methyl-α-phenyl-αmethylsuccinimide, of BP 121° to 122°C at 0.1 mm is obtained. After recrystallization from aqueous ethanol, this compound melts at 52° to 53°C.
  • brand nameCelontin (Parke-Davis).
  • Therapeutic FunctionAnticonvulsant
  • Clinical UseAlthough methsuximide is less commonly used, it may be indicated for the control of absence seizures refractory to other drugs. Although it does not precipitate tonic-clonic convulsions, it often is combined with phenytoin or phenobarbital when absence seizures coexist with tonic-clonic symptoms. Much of the efficacy of methsuximide is attributed to its desmethyl metabolite. The half-life of methsuximide is between 2.6 and 4.0 hours, but the half-life for N-desmethylsuximide is 25 hours, causing it to accumulate substantially. Concentrations of greater than 40 g/mL may be associated with toxicity. Methsuximide is considered to be more toxic than ethosuximide.
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