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METHSUXIMIDE

METHSUXIMIDE Structure
METHSUXIMIDE
  • CAS No.77-41-8
  • Chemical Name:METHSUXIMIDE
  • CBNumber:CB2695398
  • Molecular Formula:C12H13NO2
  • Formula Weight:203.24
  • MOL File:77-41-8.mol
METHSUXIMIDE Property
  • Melting point: :52-53°
  • Boiling point: :bp0.1 121-122°
  • Density  :1.1255 (rough estimate)
  • refractive index  :1.5440 (estimate)
  • storage temp.  :Refrigerator
  • Water Solubility  :2.8g/L(25 ºC)
  • FDA UNII :0G76K8X6C0
  • ATC code :N03AD03
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H412
  • Precautionary statements P301+P312+P330
METHSUXIMIDE Price More Price(10)
  • Brand: Sigma-Aldrich
  • Product number: 1422001
  • Product name : Methsuximide
  • Purity: 
  • Packaging: 500mg
  • Price: $366
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 19058
  • Product name : Methsuximide
  • Purity: ≥98%
  • Packaging: 10mg
  • Price: $31
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 19058
  • Product name : Methsuximide
  • Purity: ≥98%
  • Packaging: 25mg
  • Price: $74
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TRC
  • Product number: M271900
  • Product name : Methsuximide
  • Purity: 
  • Packaging: 100mg
  • Price: $185
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: American Custom Chemicals Corporation
  • Product number: API0001928
  • Product name : CELONTIN
  • Purity: 95.00%
  • Packaging: 50MG
  • Price: $697.34
  • Updated: 2021/12/16
  • Buy: Buy

METHSUXIMIDE Chemical Properties,Usage,Production

  • Description Methsuximide is a succinimide that is converted to N-desmethylmethosuximide, a channel blocker that targets low threshold calcium currents. Methsuximide is a substrate of cytochrome P450 (CYP) isoform 2C19 that, in turn, inhibits CYP2C19-mediated metabolism of biguanides. Methsuximide has been shown to have anticonvulsant properties in clinical trials.
  • Chemical Properties Light Yellow Oil
  • Originator Celontin,Parke Davis,US,1957
  • Uses A calcium channel succinimide antiepileptic drug. Anticonvulsant.
  • Manufacturing Process 100 g of α-phenyl-α-methylsuccinic acid and 110 g of 40% aqueous methyl amine are heated together at 200 to 250°C until no more distillate is obtained. Upon vacuum distillation of the residue, the N-methyl-α-phenyl-αmethylsuccinimide, of BP 121° to 122°C at 0.1 mm is obtained. After recrystallization from aqueous ethanol, this compound melts at 52° to 53°C.
  • brand name Celontin (Parke-Davis).
  • Therapeutic Function Anticonvulsant
  • Clinical Use Although methsuximide is less commonly used, it may be indicated for the control of absence seizures refractory to other drugs. Although it does not precipitate tonic-clonic convulsions, it often is combined with phenytoin or phenobarbital when absence seizures coexist with tonic-clonic symptoms. Much of the efficacy of methsuximide is attributed to its desmethyl metabolite. The half-life of methsuximide is between 2.6 and 4.0 hours, but the half-life for N-desmethylsuximide is 25 hours, causing it to accumulate substantially. Concentrations of greater than 40 g/mL may be associated with toxicity. Methsuximide is considered to be more toxic than ethosuximide.
METHSUXIMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
Global(56)Suppliers
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