Delapril (5-20 mg/kg, fed in drinking water) slows the progression of atherosclerosis in cholesterol-fed rabbits[2].
Delapril (1-10 mg/kg, p.o., daily for 5 weeks) shows antihypertensive effect spontaneously in hypertensive rats[3].
| Animal Model: | Cholesterol-fed rabbits[2] |
| Dosage: | 5 mg/kg at D5, 10 mg/kg at D10, 20 mg/kg at D20 |
| Administration: | Fed in a fixed volume (10 ml) of drinking water |
| Result: | Decreased aortic area covered by lesions.
Restored endothelium-dependent relaxation
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