Histone H3K36Me2 (21-44)-GK-biotin (trifluoroacetate salt)

Histone H3K36Me2 (21-44) is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and H3.2 sequences. It is dimethylated at lysine 36 and biotinylated via a C-terminal GK linker. Dimethylation of H3K36 is enriched at coding regions of genes and correlates with the initiation, but not maintenance, of active transcription.1,2WARNING This product is not for human or veterinary use.

[1] BING LI. Histone H3 lysine 36 dimethylation (H3K36me2) is sufficient to recruit the Rpd3s histone deacetylase complex and to repress spurious transcription.[J]. The Journal of Biological Chemistry, 2009: 7970-7976. DOI: 10.1074/jbc.m808220200
[2] BHARGAVI RAO. Dimethylation of histone H3 at lysine 36 demarcates regulatory and nonregulatory chromatin genome-wide.[J]. Molecular and Cellular Biology, 2005: 9447-9459. DOI: 10.1128/mcb.25.21.9447-9459.2005