TYRPHOSTIN AG 1288

Tyrphostin AG 1288 is a potent Tyrosine Kinase inhibitor. Tyrphostin AG 1288 inhibits ICAM1 expression and TNFα-mediated cytotoxicity in vitro[1].

ChEBI: 2-[(3,4-dihydroxy-5-nitrophenyl)methylidene]propanedinitrile is a nitrophenol.

[1] Burke-Gaffney A, et al. Tumour necrosis factor-alpha-induced ICAM-1 expression in human vascular endothelial and lung epithelial cells: modulation by tyrosine kinase inhibitors. Br J Pharmacol. 1996 Nov;119(6):1149-58. DOI:10.1111/j.1476-5381.1996.tb16017.x