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NONACTIN

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NONACTIN Basic information
NONACTIN Chemical Properties
  • Melting point:147-148°
  • Boiling point:890.6±65.0 °C(Predicted)
  • Density 1.11-1.15 g/cm3
  • storage temp. 2-8°C
  • solubility chloroform: soluble10mg/mL
  • form White to off-white crystalline solid.
  • color white to faint yellow
  • Sensitive Moisture Sensitive
  • Merck 13,6709
  • BRN 76434
Safety Information
  • Hazard Codes Xi
  • Safety Statements 22-24/25
  • WGK Germany 3
  • RTECS RH1685000
  • 10-21
  • HS Code 29321900
  • ToxicityLD50 intravenous in mouse: 246mg/kg
MSDS
NONACTIN Usage And Synthesis
  • Chemical PropertiesLight yellow powder
  • UsesNonactin is the smallest member of the macrotetrolide complex produced by a range of Streptomyces species. Originally the name, nonactin, reflected the lack of biological activity. The literature is confusing in this respect, as virtually all sources of nonactin are contaminated with small amounts of the much more active monactin. The BioAustralis nonactin has been purified to remove traces of other biologically-active macrotetrolides. Like the other macrotetrolides, nonactin is a monovalent cation ionophore with high selectivity for ammonium and potassium.
  • Biological ActivityMonovalent cation ionophore that displays selectivity for K + and NH 4 + (K + = NH 4 + > Na + > Mg 2+ > Li + >> Ca 2+ for nonactin-EVA sensor). Induces cation transport across artificial membranes. Also inhibits P-glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug resistant cancer cells. Antibiotic.
  • Purification MethodsThis macrotetrolide antibiotic crystallises from MeOH as colourless needles and is dried at 90o/20hours/high vacuum. [Cordaz et al. Helv Chim Acta 38 1445 1955, crystal structure: Dobler Helv Chim Acta 55 1371 1972, Gambos et al. Tetrahedron Lett 3391 1975, Beilstein 19/12 V 751.]
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