Factory high quality and low price NONACTIN | China | Manufacturer

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NONACTIN Basic information

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Product Name:

NONACTIN

Synonyms:

AMMONIUM IONOPHORE;AMMONIUM IONOPHORE I;WERRAMYCIN A;-(1r*,2r*,5r*,7r*,10s*,11s*,14s*,16s*,19r*,20r*,23r*,25r*,28s*,29s*,32s*,34s*);28))tetracontane-3,12,21,30-tetrone,2,5,11,14,20,23,29,32-octamethyl-2(1r;3584-a;fh-3582-a;n-329-a

CAS:

6833-84-7

MF:

C40H64O12

MW:

736.93

EINECS:

229-911-3

Product Categories:

inhibitor

Mol File:

6833-84-7.mol

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NONACTIN Chemical Properties

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Melting point

147-148°

Boiling point

890.6±65.0 °C(Predicted)

density

1.11-1.15 g/cm3

storage temp.

2-8°C

solubility

chloroform: soluble10mg/mL

form

White to off-white crystalline solid.

color

white to faint yellow

Sensitive

Moisture Sensitive

Merck

13,6709

BRN

76434

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Safety Information

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Hazard Codes

Xi

Safety Statements

22-24/25

WGK Germany

3

RTECS

RH1685000

F

10-21

HS Code

29321900

Toxicity

LD50 intravenous in mouse: 246mg/kg

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MSDS Information

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Provider

Language

SigmaAldrich

English

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NONACTIN Usage And Synthesis

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Chemical Properties

Light yellow powder

Uses

Nonactin is the smallest member of the macrotetrolide complex produced by a range of Streptomyces species. Originally the name, nonactin, reflected the lack of biological activity. The literature is confusing in this respect, as virtually all sources of nonactin are contaminated with small amounts of the much more active monactin. The BioAustralis nonactin has been purified to remove traces of other biologically-active macrotetrolides. Like the other macrotetrolides, nonactin is a monovalent cation ionophore with high selectivity for ammonium and potassium.

Biological Activity

Monovalent cation ionophore that displays selectivity for K + and NH 4 + (K + = NH 4 + > Na + > Mg 2+ > Li + >> Ca 2+ for nonactin-EVA sensor). Induces cation transport across artificial membranes. Also inhibits P-glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug resistant cancer cells. Antibiotic.

Purification Methods

This macrotetrolide antibiotic crystallises from MeOH as colourless needles and is dried at 90o/20hours/high vacuum. [Cordaz et al. Helv Chim Acta 38 1445 1955, crystal structure: Dobler Helv Chim Acta 55 1371 1972, Gambos et al. Tetrahedron Lett 3391 1975, Beilstein 19/12 V 751.]

Product Name	NONACTIN
CAS No	6833-84-7
EC-No	229-911-3
Min. Order	1g
Purity	≥98%
Supply Ability	g/kg/Ton
Release date	2019/12/26

NONACTIN

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