Methionine sulfoximine (2-Amino-4-(S-methylsulfonimidoyl)butanoic acid) is an irreversible inhibitor of glutamine synthetase with convulsive effects. Methionine sulfoximine is able to affect the metabolism of glutamate and glutamine, which may provide important insights in neurobiological research. Methionine sulfoximine has also been used to study mechanisms related to epilepsy and its inhibitory potential[1].
ChEBI: A non-proteinogenic alpha-amino acid that is the sulfoximine derivative of methionine .
[1] Catalytic cooperativity and subunit interactions in Escherichia coli glutamine synthetase: binding and kinetics with methionine sulfoximine and related inhibitors
