Clear pale yellow-greenish liquid
2-Propanesulfonyl chloride is used as a pharmaceutical intermediate. Reductive cleavage of a secondary alcohol to methylene has been achieved by reduction of the 2-propanesulfonyl ester with lithium triethylborohydride.
2-Propanesulfonyl chloride (isopropylsulfonyl chloride) can be used as a reactant to prepare:
- 1-Isopropylsulfonyl-2-amine benzimidazole by reacting with 2-aminobenzimidazole via N-sulfonylation reaction in the presence of a base.
- Bis(isopropylsulfonyl)disulfide, a sulfurizing agent, used to synthesize phosphorothioate oligonucleotide analogs.
The solvolysis of 2-propanesulfonyl chloride by an addition-elimination (association-dissociation) pathway was studied.
