4,5-DICHLOROPHTHALIMIDE

4,5-Dichlorophthalimide (5,6-dichloro-1H-isoindole-1,3(2H)-dione) is suitable as a reactant in the synthesis of 5′-N-(4′′,5′′-dichlorophthaloyl)-3′-azido-2′,3′-dideoxythymidine and 2-amino-4,5-dichlorobenzoic acid.
It may be used in the following studies:

• As a reactant in the synthesis of 4,5-dichloro-1,2-benzenedicarboxamide.
• As an additive in the Ir-BICP catalyzed asymmetric hydrogenation of 2,3,3-trimethylindolenine to improve enantioselectivity.
• As a reactant in the synthesis of octachloro-Cu-phthalocyanine.
• As a reagent in the synthesis of 7-tert-butylthianthrene-2,3-dicarboxylic imide.
• As a starting material in the synthesis of N-(3-bromopropyl)-4,5-dichlorophthalimide.
• As a nucleophilic partner in the phosphine-catalyzed allylic substitution of Morita-Baylis-Hillman acetates to form N-protected β-amino phosphonic acid esters.

4,5-Dichlorophthalimide (5,6-dichloro-1H-isoindole-1,3(2H)-dione) is a phthalimide derivative. It has been synthesized from 5,6-dichloro-1,3-isobenzofurandione and characterized by ¹H ,¹³C-NMR and IR. The dipole moment, polarizability and first-order hyperpolarizability of 4,5-dichlorophthalimide have been investigated using ab initio and density functional theory calculations.