GENERAL METHODS: 2-methoxypyrimidine (1c, 0.216 mg, 2 mmol) was mixed with acetyl chloride (2a, 0.157 mg, 2 mmol), and CTAB or CTAC (0.001 mol) was added as a catalyst and dissolved in dichloroethane. The reaction mixture was heated in a microwave synthesizer (Biotage Initiator+ SP Wave model, power 0.200 W, frequency 2.45 GHz, capped at 60 W at steady state) for 5 min, and the reaction conditions were controlled to be at 100 °C and 2 bar pressure. Upon completion of the reaction, the target product 1-(2-methoxypyrimidin-5-yl)ethanone (3o) was isolated and purified by column chromatography using silica gel as stationary phase and mixed solvent of ethyl acetate-petroleum ether as eluent.
