(-)-反式-3-(3,4-亚甲基二氧基苄基)-2-(3,4,5-三甲氧基苄基)丁内酯
英文名称:(3R)-3α-(3,4,5-Trimethoxybenzyl)-4β-(1,3-benzodioxole-5-ylmethyl)tetrahydrofuran-2-one
CAS号:40456-50-6
分子式:C22H24O7
分子量:400.42
EINECS号:
Mol文件:40456-50-6.mol
(-)-反式-3-(3,4-亚甲基二氧基苄基)-2-(3,4,5-三甲氧基苄基)丁内酯 性质
| 沸点 | 564.9±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.266±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 颜色 | 无色至浅黄 |
(-)-反式-3-(3,4-亚甲基二氧基苄基)-2-(3,4,5-三甲氧基苄基)丁内酯 用途与合成方法
Yatein 是从 A. chilensis 中提取的木质素，具有抗增殖活性。Yatein 能通过中断立早基因的表达，抑制单纯疱疹病毒 1 型 (HSV-1) 的复制。
HSV-1
Yatein induces cell-cycle arrest at G2/M phase (5 μM; 24 hours) and enhances G2/M phase-related protein expression (5 μM; 6-12 hours) in human lung adenocarcinoma A549 and CL1-5 cells.
Yatein (5 μM; 6-12 hours) induces DNA damage through activation of the ATM/ATR pathway in human A549 and CL1-5 cells.
Yatein (5 μM; 6 hours) affects microtubule dynamics by inhibiting tubulin polymerization.
Cell Viability Assay
| Cell Line: | A549 cells, CL1-5 cells |
| Concentration: | 1.25 μM , 2.5 μM , 5 μM |
| Incubation Time: | 24 hours |
| Result: | Induced cell-cycle arrest at G2/M phase in both cell lines. |
Cell Viability Assay
| Cell Line: | A549 cells, CL1-5 cells |
| Concentration: | 5 μM |
| Incubation Time: | 6 hours, 12 hours |
| Result: | Upregulated the expression of cyclin B1, but not Cdc2 and Cdc25c, induced Cdc2 phosphorylation. |
Yatein (20 mg/kg; i.p.; five times per week; for 42 days) exhibits in vivo antitumor effects in a human lung adenocarcinoma xenograft mouse model.
| Animal Model: | Male NOD/SCID mice (6-8 weeks), with A549 cells xenograft |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection, five times per week, for 42 days |
| Result: | Significantly slowed tumor growth and moderately increased both cyclin B1 expression and Cdc2 phosphorylation. |
(-)-反式-3-(3,4-亚甲基二氧基苄基)-2-(3,4,5-三甲氧基苄基)丁内酯供应商 更多
云南西力生物技术股份有限公司
联系电话：0871-65217109 13211707573;
产品介绍：
英文名称：Yatein
CAS：40456-50-6
纯度：96.5%
包装信息：5mg
备注：BBP02041
武汉天植生物技术有限公司
联系电话：18607101326 15172504745
产品介绍：
中文名称：亚太因
英文名称：Yatein
CAS：40456-50-6
纯度：>=98%
包装信息：5mg ,10mg ,20mg ,50mg ,100mg; 200mg; 500mg or according to customer requirements
备注：标准品
上海源叶生物科技有限公司
联系电话：021-61312847; 18021002903
产品介绍：
中文名称：亚太因
英文名称：Yatein
CAS：40456-50-6
纯度：HPLC≥95%
包装信息：5mg
备注：生化试剂
