WARANGALONE
WARANGALONE 性质
| 熔点 | 164-165 °C |
|---|---|
| 沸点 | 627.0±55.0 °C(Predicted) |
| 密度 | 1.258±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 酸度系数(pKa) | 6.39±0.40(Predicted) |
| 颜色 | 浅黄至黄色 |
WARANGALONE 用途与合成方法
IC50: 4.8 μg/mL (3D7), 3.7 μg/mL (K1)
IC50: 3.5 μM (cAK)
Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC 50 s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC 50 of 3.5 μM. When HL-60 cells are exposed to Warangalone (30 μM) for 24 h, Warangalone induces a significant decrease (8%) in cell viability compare to controls. Warangalone also inhibits HL-60 cell growth within 24 h in a time-dependent fashion. A time-dependent increase in caspase-9 activity is observed in Warangalone-treated cells.
