Hemokinin 1 is an 11-amino acid tachykinin neuropeptide with roles in pain transmission and inflammation and is a neurokinin-1 (NK1) receptor agonist.1,2 It is primarily expressed in immune cells and, to a lesser extent, in the brain.3 Hemokinin 1 binds to NK1 receptors (Ki = 0.175 nM) and induces contractions in isolated rat urinary bladder (EC50 = 100 nM).1 Knockdown of Tac4, the gene encoding hemokinin 1, inhibits neurogenic inflammation-induced mechanical and thermal hypersensitivity and visceral nocifensive behavior in mice.3 Tac4-/- mice also exhibit impaired inflammatory responses to intranasal administration of E. coli LPS.4WARNING This product is not for human or veterinary use.
