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Sodium thioglycolate

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Sodium thioglycolate Basic information
Sodium thioglycolate Chemical Properties
  • Melting point:>300 °C (lit.)
  • vapor pressure <0.1 hPa (25 °C)
  • storage temp. -20°C
  • solubility 609.1g/l
  • form solid
  • color White powder
  • OdorStench odour
  • PH Range6.5 - 8 at 114 g/l at 25 °C
  • PH6.7 (100g/l, H2O, 20℃)
  • Water Solubility soluble
  • Sensitive Air Sensitive & Hygroscopic
  • Merck 14,8692
  • BRN 4569109
  • CAS DataBase Reference367-51-1(CAS DataBase Reference)
  • EPA Substance Registry SystemSodium thioglycolate (367-51-1)
Safety Information
  • Hazard Codes Xn
  • Risk Statements 22-38-36/37/38
  • Safety Statements 36-28-26
  • RIDADR 2811
  • WGK Germany 1
  • RTECS AI7700000
  • 3-10-13-23
  • TSCA Yes
  • HazardClass 6.1(b)
  • PackingGroup III
  • HS Code 29309070
  • ToxicityLD50 i.p. in rats: 148 mg/kg, Freeman, Rosenthal, Fed. Proc. 11, 347 (1952)
Sodium thioglycolate Usage And Synthesis
  • Chemical PropertiesWhite solid
  • Usesdipilatory, irritant, chelating agent
  • UsesIn cold-waving of hair; as depilatory; in bacteriology for the preparation of thioglycolate media; as analytical reagent, see Thioglycolic Acid.
  • Uses
    Sodium thioglycolate has been used:
    • as a growth supplement in enrichment media and to study its effect on Arcobacter
    • in influenza hemagglutinin formulation in order to reduce disulfide-mediated cross-linking and early potency loss
    • in electron microscopy

  • DefinitionThe sodium salt of thioglycolic acid.
  • General DescriptionWhite powder with a slight odor. Used in cold-waving of hair and as a dipilatory.
  • Air & Water ReactionsHygroscopic. Discolors on exposure to air. Water soluble.
  • Reactivity ProfileSodium thioglycolate is hygroscopic and sensitive to air. Discolors if exposed to iron . May generate flammable and toxic hydrogen sulfide with strong reducing agents.
  • HazardYields toxic hydrogen sulfide on decompo- sition, may be toxic by skin absorption.
  • Fire HazardFlash point data for Sodium thioglycolate are not available. Sodium thioglycolate is probably combustible.
  • Biochem/physiol ActionsSodium thioglycolate is a commonly used reagent for bacteriological research to maintain reducing conditions in media. Thioglycolate can also protect enzymes against inactivation by maintaining protein thiol groups in the reduced state. Thioglycolate medium is frequently used in inflammation research to elicit a neutrophil and macrophage response in vivo.
  • Safety ProfilePoison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. A human skin irritant. This material yields hydrogen sulfide on decomposition. A death has been attributed to the absorption of toxic decomposition products from the use of this material in a hair permanent-waving solution. When heated to decomposition it emits toxic fumes of SOx and Na2O. See also SULFIDES and MERCAPTANS.
  • Purification MethodsIt crystallises from 60% EtOH (charcoal). It is hygroscopic.[Beilstein 3 IV 600.]
Sodium thioglycolate(367-51-1)Related Product Information
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