Carbamic acid, N-[4-[[(4-fluorophenyl)methyl]-2-propyn-1-ylamino]-2,6-dimethylphenyl]-, methyl ester

HN37 as a potent and chemically stable antiepileptic agent candidate, with an EC50 of 37 nM for KCNQ2[1]. HN37 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HN37 as a potent and chemically stable antiepileptic drug candidate, with an EC50 of 37 nM for KCNQ2[1]. HN37 is a potent neuronal Kv7 activator with a subtype selectivity similar to RTG[1].

[1]. Yang-Ming Zhang, et al. Discovery of HN37 as a Potent and Chemically Stable Antiepileptic Drug Candidate. J Med Chem. 2021 May 13;64(9):5816-5837.