T-2513
中文名称:T-2513
英文名称:1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 9-(3-aminopropoxy)-4,11-diethyl-4-hydroxy-, (4S)-
CAS号:288247-87-0
分子式:C25 H27 N3 O5
分子量:449.5
EINECS号:
Mol文件:288247-87-0.mol
T-2513 用途与合成方法
T-2513 是一种选择性的拓扑异构酶 I (topoisomerase I) 抑制剂。T-2513 与拓扑异构酶 I-DNA 复合物共价结合并使其稳定，且抑制 DNA 复制和 RNA 合成，最终导致细胞死亡。
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Topoisomerase I
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SN-38 is the metabolite of T-2513.
T-2513 has a broad cytotoxicity against a range of human tumor cell lines.
Cell Cytotoxicity Assay
| Cell Line: | WiDr, HT-29, SK-BR-3, MKN-1, SK-LU-1, LX-1, KB, and HeLaS3 cells |
| Concentration: | 15.1-111.5 ng/mL |
| Incubation Time: | 24 hours |
| Result: | Exhibited cytotoxicity against a panel of human tumor cell lines with GI 50 s of 32.1, 97.6, 38.6, 15.6, 111.5, 15.1, 34.0, and 50.9 ng/mL for WiDr, HT-29, SK-BR-3, MKN-1, SK-LU-1, LX-1, KB, and HeLaS3 cells, respectively. |
T-2513 (1-100 mg/kg) shows Antitumor Activity against Walker-256 carcinoma.
| Animal Model: | Rats bearing Walker-256 carcinoma |
| Dosage: | 1, 10, and 100 mg/kg |
| Administration: | |
| Result: | The ED 50 was 23 mg/kg. |
T-2513供应商 更多
天津普西唐生物医药科技有限公司
联系电话：010-60605840 15801484223;
产品介绍：
英文名称：T-2513
CAS：288247-87-0
包装信息：100mg;250mg;500mg
备注： 试剂级
TargetMol中国（陶术生物）
联系电话： 15002134094
产品介绍：
中文名称：T-2513
英文名称：T-2513
CAS：288247-87-0
包装信息：25mg/RMB 10600
