T-2513

CAS号:288247-87-0
英文名:1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 9-(3-aminopropoxy)-4,11-diethyl-4-hydroxy-, (4S)-
中文名:T-2513
CBNumber:CB18129252
分子式:C25 H27 N3 O5
分子量:449.5
MOL File:288247-87-0.mol

T-2513化学性质

T-2513性质、用途与生产工艺

生物活性 T-2513 是一种选择性的拓扑异构酶 I (topoisomerase I) 抑制剂。T-2513 与拓扑异构酶 I-DNA 复合物共价结合并使其稳定，且抑制 DNA 复制和 RNA 合成，最终导致细胞死亡。
靶点

Topoisomerase I

体外研究

SN-38 is the metabolite of T-2513.
T-2513 has a broad cytotoxicity against a range of human tumor cell lines.

Cell Cytotoxicity Assay

Cell Line:	WiDr, HT-29, SK-BR-3, MKN-1, SK-LU-1, LX-1, KB, and HeLaS3 cells
Concentration:	15.1-111.5 ng/mL
Incubation Time:	24 hours
Result:	Exhibited cytotoxicity against a panel of human tumor cell lines with GI ₅₀ s of 32.1, 97.6, 38.6, 15.6, 111.5, 15.1, 34.0, and 50.9 ng/mL for WiDr, HT-29, SK-BR-3, MKN-1, SK-LU-1, LX-1, KB, and HeLaS3 cells, respectively.

体内研究

T-2513 (1-100 mg/kg) shows Antitumor Activity against Walker-256 carcinoma.

Animal Model:	Rats bearing Walker-256 carcinoma
Dosage:	1, 10, and 100 mg/kg
Administration:
Result:	The ED ₅₀ was 23 mg/kg.

T-2513上下游产品信息

上游原料

下游产品

T-2513生产厂家