5-Bromoisophthalaldehyde

51760-22-6

120173-41-3

General procedure for the synthesis of 5-bromoisophthalaldehyde from 5-bromo-1,3-dihydroxymethylbenzene: Manganese(IV) dioxide (35.5 g, 408 mmol) was added to a solution of 5-bromo-1,3-phenylenedimethanol (3.60 g, 16.6 mmol) in tetrahydrofuran (250 mL) and the reaction was heated for 4 hr at 60 °C. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to remove the solvent. The final 5-bromoisophthalaldehyde (1.61 g, 46% yield) was obtained as a white solid.