BW 723C86

Product NameBW 723C86
CAS160521-72-2
MFC16H19ClN2OS
MW322.85
EINECS
MOL File160521-72-2.mol

Chemical Properties

storage temp.	Desiccate at +4°C
solubility	DMSO: >10 mg/mL
form	solid
color	white
Water Solubility	H2O: 1mg/mL, clear
InChI	1S/C16H18N2OS.ClH/c1-11(17)7-12-9-18-16-5-4-13(8-15(12)16)19-10-14-3-2-6-20-14;/h2-6,8-9,11,18H,7,10,17H2,1H3;1H
InChIKey	PYJBJMIBANAOFJ-UHFFFAOYSA-N
SMILES	Cl.CC(N)Cc1c[nH]c2ccc(OCc3cccs3)cc12

Safety Information

WGK Germany	3
RTECS	NL8504715
Storage Class	11 - Combustible Solids

MSDS

Provider	Language
SigmaAldrich	English

Usage And Synthesis

Uses

BW 723C86 is a selective 5-HT2B receptor agonist. It is used in the treatment of certain CNS disorders, in particular epilepsy, migraine and feeding disorders.

Biological Activity

Selective 5-HT 2B receptor agonist.

Biochem/physiol Actions

5-HT2B serotonin receptor agonist.

in vivo

BW-723C86 (1-20 mg/kg, s.c., 30 min pre-test (grooming)) causes hyperphagia and decreased grooming in rats, with increasing the time spent in feeding behaviour^[2].
BW-723C86 (10-30 mg/kg, i.p. 30 min pre-test) shows anxiolytic effects in rats via 5-HT_2B receptor^[3].
BW-723C86 (3-10 mg/kg, s.c. 30 min pretest) exerts an appreciable anxiolytic-like profile in rats, with increasing total social interaction^[4].
BW-723C86 (5 mg/kg, p.o., 20 or 30 min before the liquid meal) inhibits liquid meal-induced gastric accommodation in normal Hartley guinea pigs^[5].

Animal Model:	Male Sprague Dawley (CD) rats (220–250 g) for vogel conflict test^[3]
Dosage:	0.3, 1, 3, 10, 30 mg/kg
Administration:	Intraperitoneal injection (i.p.), 30 min pre-test
Result:	Increased the number of punishments accepted in the rat Vogel conflict test over 3 min. Had no significant effect on either the amount of time spent drinking or the latency to drink. Did not affect apparent shock sensitivity.

IC 50

5-HT_2B Receptor

storage

Desiccate at +4°C

References

[1]. kennett ga, bright f, trail b, et al. effects of the 5-ht2b receptor agonist, bw 723c86, on three rat models of anxiety. br j pharmacol, 1996, 117(7): 1443-1448.
[2]. dergacheva o, wang x, kamendi h, et al. 5ht2 receptor activation facilitates p2x receptor mediated excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguus. neuropharmacology, 2008, 54(7): 1095-1102.
[3]. kennett ga, trail b, bright f. anxiolytic-like actions of bw 723c86 in the rat vogel conflict test are 5-ht2b receptor mediated. neuropharmacology, 1998, 37(12): 1603-1610.
[4]. urtikova n, berson n, van steenwinckel j, et al. antinociceptive effect of peripheral serotonin 5-ht2b receptor activation on neuropathic pain. pain, 2012, 153(6): 1320-1331.

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