4-Hydroxypiperidine hydrochloride

Product Name4-Hydroxypiperidine hydrochloride
CAS5382-17-2
MFC5H12ClNO
MW137.61
EINECS226-374-7
MOL File5382-17-2.mol

Chemical Properties

Melting point	155-157 °C(lit.)
storage temp.	Inert atmosphere,Room Temperature
solubility	methanol: soluble25mg/mL, clear, colorless
form	powder to crystaline
color	White to Orange to Green
Water Solubility	very faint turbidity
BRN	3908995
InChI	1S/C5H11NO.ClH/c7-5-1-3-6-4-2-5;/h5-7H,1-4H2;1H
InChIKey	VKCORPXOKYDINR-UHFFFAOYSA-N
SMILES	Cl[H].OC1CCNCC1
CAS DataBase Reference	5382-17-2(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
F	3
HS Code	29333990
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

MSDS

Provider	Language
SigmaAldrich	English

Usage And Synthesis

Chemical Properties

White powder

Uses

4-Hydroxypiperidine hydrochloride is suitable for use in the Ugi-multi component reaction (MCR) to study the use of miniaturised-synthesis and Total Analysis System (mSYNTAS) in solution phase synthesis and on-line analysis of Ugi-MCRs. It may be used in the synthesis of acetic acid-piperidine-4-yl ester.

Uses

4-Hydroxypiperidine, HCl

General Description

4-Hydroxypiperidine hydrochloride is a piperidine derivative. The synthesis of 4-hydroxypiperidine has been reported. 4-Hydroxypiperidine participates in the synthesis of 4-(4′-hydroxypiperidino)-4-phenylcyclohexanol and 1-(4-hydroxypiperidino)cyclohexanecarbonitrile. 4-Hydroxypiperidine is the starting material for the synthesis of Sibrafiban and Lamifiban, two non-peptidefibrinogen receptor.

Synthesis

109384-19-2

5382-17-2

The general procedure for the synthesis of 4-hydroxypiperidine hydrochloride from N-Boc-4-hydroxypiperidine was as follows: tert-butyl 4-hydroxypiperidine-1-carboxylate (5 g, 24.84 mmol, 1.00 eq.) was mixed with a saturated HCl solution dissolved in 30 mL of 1,4-dioxane, and the reaction was stirred for 2 h at room temperature. Upon completion of the reaction, the mixture was concentrated in vacuum to afford 4-hydroxypiperidine hydrochloride (3.4 g, 99% yield) as an off-white solid.

References

[1] Patent: WO2015/52264, 2015, A1. Location in patent: Paragraph 0918; 0919
[2] Patent: WO2017/153520, 2017, A1. Location in patent: Page/Page column 50
[3] Patent: WO2016/34673, 2016, A1. Location in patent: Page/Page column 120

4-Hydroxypiperidine hydrochloride

Chemical Properties

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MSDS

Usage And Synthesis

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