Strychnine hydrochloride has been used as a glycine receptor antagonist in the retina for biophysiological functions. It has also been used to block glutamatergic, GABAergic and glycinergic receptors and gap junctions.
Strychnine Hydrochloride acts as an antagonist for cholinesterases and beta amyloid aggregation.
ChEBI: A hydrochloride obtained by combining strychnine with one molar equivalent of hydrogen chloride.
Competitive glycine receptor antagonist; convulsant. Also nicotinic receptor antagonist; displays competitive antagonism at α 7 receptors and non-competitive antagonism at α 4 β 2 receptors.
Strychnine is a potent convulsant, which is extracted from Strychnos nux vomica seeds. At high doses, the compound causes convulsions and ultimately death due to respiratory paralysis. Strychnine acts as a respiratory, circulatory and digestive stimulant.
