1H-Indole-3-carboxylic acid hydrazide

942-24-5

15317-58-5

GENERAL PROCEDURE: Methyl indole-3-carboxylate (5 mmol) was slowly added to hydrazine hydrate (80%, 3 mL) at room temperature. Subsequently, the reaction mixture was subjected to continuous microwave irradiation at 300 W for 5-8 min. The reaction process was monitored by thin layer chromatography (TLC). Once the reaction was complete, the mixture was cooled sufficiently to room temperature to afford the intermediate indole-3-carbohydrazide in 83-98% yield.