CFM 4

CFM-4 (331458-02-7) is a CARP-1 functional mimetic that interferes with CARP-1 binding to APC-2 (IC50=10-15 μM).1 Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses growth of medulloblastoma cells2 and malignant pleural mesothelioma cells3.

CFM-4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM-4 prevents CARP-1 binding with APC-2, causes G2M cell cycle arrest, and induces apoptosis with an IC50 range of 10-15 μM. CFM-4 also suppresses growth of drug-resistant human breast cancer cells[1].

[1] VINESHKUMAR THIDIL PULIYAPPADAMBA. Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis.[J]. The Journal of Biological Chemistry, 2011: 38000-38017. DOI:10.1074/jbc.m111.222398
[2] ABDELKADER E ASHOUR. CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth.[J]. PLoS ONE, 2013: e66733. DOI:10.1371/journal.pone.0066733
[3] SHAZIA JAMAL. CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells.[J]. PLoS ONE, 2014: e89146. DOI:10.1371/journal.pone.0089146