Uses
CFM-4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM-4 prevents CARP-1 binding with APC-2, causes G2M cell cycle arrest, and induces apoptosis with an IC50 range of 10-15 μM. CFM-4 also suppresses growth of drug-resistant human breast cancer cells[1].
References
[1] VINESHKUMAR THIDIL PULIYAPPADAMBA. Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis.[J]. The Journal of Biological Chemistry, 2011: 38000-38017. DOI:
10.1074/jbc.m111.222398[2] ABDELKADER E ASHOUR. CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth.[J]. PLoS ONE, 2013: e66733. DOI:
10.1371/journal.pone.0066733[3] SHAZIA JAMAL. CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells.[J]. PLoS ONE, 2014: e89146. DOI:
10.1371/journal.pone.0089146
