Description
BML-259 (267654-00-2) is a potent inhibitor of Cdk5/p25 (IC50 = 64 nM) and Cdk2 (IC50 = 98nM).1
Uses
BML-259 is a potent cyclin-dependent kinase 5 (Cdk5) inhibitor, with IC50s of 64 and 98 nM for Cdk5 and Cdk2, respectively[1].
Definition
ChEBI: 2-phenyl-N-(5-propan-2-yl-2-thiazolyl)acetamide is a member of acetamides.
References
[1] CHRISTOPHER J. HELAL. Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease[J]. Bioorganic & Medicinal Chemistry Letters, 2004, 14 22: Pages 5521-5525. DOI:
10.1016/j.bmcl.2004.09.006
