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Amylamine Basic information
Amylamine Chemical Properties
  • Melting point:−55 °C(lit.)
  • Boiling point:104 °C(lit.)
  • Density 0.752 g/mL at 25 °C(lit.)
  • vapor density 3.01 (vs air)
  • vapor pressure 120.9 hPa (47 °C)
  • refractive index n20/D 1.411(lit.)
  • Flash point:42 °F
  • storage temp. Flammables area
  • solubility Soluble in alcohol, ether.
  • pka10.63(at 25℃)
  • form Liquid
  • color Clear colorless to very slightly yellow
  • explosive limit2.2-22%(V)
  • Water Solubility soluble
  • Sensitive Air Sensitive
  • JECFA Number1585
  • Merck 14,598
  • BRN 505953
  • CAS DataBase Reference110-58-7(CAS DataBase Reference)
  • NIST Chemistry Reference1-Pentanamine(110-58-7)
  • EPA Substance Registry SystemAmylamine (110-58-7)
Safety Information
  • Hazard Codes F,C
  • Risk Statements 11-22-34-42/43-20/21/22-52/53
  • Safety Statements 16-26-36/37/39-45-33-61
  • RIDADR UN 1106 3/PG 2
  • WGK Germany 3
  • RTECS SC0300000
  • 34
  • Autoignition Temperature305 °C
  • TSCA Yes
  • HazardClass 3
  • PackingGroup II
  • HS Code 29211990
  • ToxicityLD50 orally in Rabbit: 470 mg/kg LD50 dermal Rabbit 1120 mg/kg
Amylamine Usage And Synthesis
  • Chemical Propertiesclear colourless to very slightly yellow liquid
  • Chemical Propertiesn-Amylamine is a strong base in aqueous solutions and organic solvents that readily forms salts with acids.
  • Chemical PropertiesColorless to yellow liquid; fishy aroma.
  • UsesChemical intermediate, dyestuffs, rubber chemicals, insecticides, synthetic detergents, flotation agents, corrosion inhibitors, solvent, gasoline additive, pharmaceuticals.
  • Production Methodsn-Amylamine is primarily produced by the amination of alkyl halides rather than using alcohol. This reaction is carried out at a temperature of 300-500°C and a pressure of 790-3550 kPa. Alternatively, n-amylamine can be produced from the reaction of amyl chlorides with ammonia. This procedure also produces small amounts of amylenes and amyl alcohol which can be removed by steam distillation (Schweizer et al 1978).
  • Aroma threshold valuesHigh strength odor; fishy type; recommend smelling in a 0.10% solution or less.
  • General DescriptionA clear colorless liquid with an ammonia-like odor. Flash point 30°F. Irritates the eyes and respiratory system. Vapors are heavier than air. Produces toxic oxides of nitrogen during combustion. Used as a corrosion inhibitor, solvent, flotation agent and in the manufacture of other chemicals.
  • Air & Water ReactionsHighly flammable. Less dense than water and soluble in water.
  • Reactivity ProfileAMYLAMINES are amines. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Can react with oxidizing materials. [NTP 1992].
  • HazardFlammable, dangerous fire risk. Strong irritant.
  • Health HazardMay cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
  • Health HazardDirect skin contact with amylamine leads to first- and second-degree burns. Inhalation results in irritation of the mucous membranes of the nose and respiratory tract. It has been reported that in humans a concentration of 0.3 mg/1 of the inhaled n-amylamine had no irritating effect (Loit and Filou 1964).
  • Fire HazardFlammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
  • Industrial usesIn 1976, 800 tons of n-amylamine was produced for a variety of commercial purposes. It is used in textiles, lubrication and in the manufacture of dyestuffs, emulsifying agents, anti-oxidants and desizing agents for the textile and pharmaceutical industry. It is also valuable as a corrosion inhibitor and as a base for emulsifiers which are soluble in vegetable and mineral oils.
  • Safety ProfilePoison by intraperitoneal route. A corrosive. A flammable liquid. When heated to decomposition it emits toxic vapors of NOx.
  • MetabolismAs exposure to n-amylamine is often via inhalation, several studies have investigated the uptake and distribution of amylamine by lungs. For a number of aliphatic amines their uptake correlated well with their partition coefficients (between n-octanol and pH 7 buffer) (Fowler et al 1976). The amino group, as well as the relatively lipophilic alkyl group, was required for lung specificity. It was also demonstrated using inhibitors that n-amylamine was rapidly metabolized to CO2 by monoamine oxidase and that CO2 exhalation increased with increasing chain length from C4 to C13. Another study on the pharmacokinetics of n-amylamine uptake by lung demonstrated that the distribution of n-amylamine between vascular and extravascular spaces was sensitive to arterial pH, with alkalosis favoring extravascular distribution (Effros and Chihard 1969).
    The ability of n-amylamine to serve as a substrate or an inhibitor of monoamine oxidase has been addressed in a number of in vitro and in vivo studies. However, many of the results are contradictory and appear to be related to concentrationdependent phenomena. When tested in vitro, n-amylamine was reported to inhibit rat liver monoamine oxidase in a partially irreversible and noncompetitive manner (Takagi and Gomi 1966). Longer chain aliphatic amines were even more inhibitory. In contrast, at lower concentrations n-amylamine served as a substrate for monoamine oxidase. Weiner (1966) also concluded that n-amylamine was a poor substrate for monoamine oxidase isolated from rat, mouse, dog, cat, and human brains. The amine was more active towards rabbit brain monoamine oxidase. When administered intraperitoneally to rats, n-amylamine had no effect on liver monoamine oxidase activity (Valiev 1974).
    Several other studies strongly suggest that amylamine is a substrate for monoamine oxidase and is metabolized by this enzyme in vivo. McEwen (1965a) purified monoamine oxidase from human plasma and found it to be most active against several simple aliphatic amines, with butylamine being the most active substrate. Further characterization indicated that high concentrations of the amine inhibited the enzyme and that the non-ionized forms of the amines are responsible for the observed competitive inhibition (McEwen 1965b). In agreement, others reported that n-amylamine was a good substrate for monoamine oxidase purified from dog serum (Ikeno et al 1978). In another in vitro study, Kurosawa (1974) demonstrated n-amylamine to be a substrate for monoamine oxidase prepared from beef or rat liver. In vivo, it was found that, in rats, the release of 14CO2 from 14C-amylamine was significantly decreased by riboflavin or iron deficiency, conditions which also decreased monoamine oxidase activity (Sourkes and Missala 1976). These studies all indicate that amylamine is metabolized by monoamine oxidase in a variety of species.
  • Purification MethodsDry it by prolonged shaking with NaOH pellets, then distilling. Store it in a CO2-free atmosphere. [Beilstein 4 IV 674.]
Amylamine Preparation Products And Raw materials
Amylamine(110-58-7)Related Product Information
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