5,6alpha-Dihydro PGI2

6α-Prostaglandin I₁ (6α-PGI₁) is a stable Prostaglandin I₂ (PGI₂) analog resistant to hydrolysis in aqueous solutions. 6α-PGI₁ promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration dependent manner. However, it is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI₂ in eliciting the response.¹ 6α-PGI₁ exhibits an IC₅₀ of 350 ng/ml for inhibition of ADP-induced platelet aggregation, which is nearly 900-fold higher than that observed for PGI₂ (0.4 ng/ml).²

6α-Prostaglandin I1 (6α-PGI1) is an analogue of prostacycline I2 (PGI2) and is resistant to hydrolysis in aqueous solution[1].

ChEBI: 6alpha-Prostaglandin I1 is a prostaglandins I.

1. Patrono, C., Rotella, C.M., Toccafondi, R.S., et al. Prostacyclin stimulates the adenylate cyclase system of human thyroid tissue Prostaglandins 22(1),105-115(1981).
2. Whittle, B.J.R., and Moncada, S. Prostacyclin and its analogues for the therapy of thromboembolic disorders Adv. Exp. Med. Biol. 164,193-209(1984).