5,6beta-Dihydro PGI2

6β-PGI₁ is a stable PGI₂ analog resistant to hydrolysis in aqueous solutions. 6β-PGI₁ has a much longer half-life than PGI₂, but a greatly reduced molar potency for receptor mediated function. 6β-PGI₁ has a K_act for adenylate cyclase in NCB-20 cells of 4.2 μM compared with 18 nM for PGI₂. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI₂.^1,2

6β-Prostaglandin I1 (6β-PGI1) is an analog of prostaglandin I2 (PGI2) that is resistant to hydrolysis in aqueous solutions. 6β-Prostaglandin I1 can reduce gastric acid secretion with an ID50 (dose causing 50% inhibition) of approximately 3.0 μg/kg/min (intravenous injection)[1].

ChEBI: 6-Prostaglandin I1 is a prostanoid.

1. Whittle, B.J.R., Moncada, S., Whiting, F., et al. Carbacyclin — a potent stable prostacyclin analogue for the inhibition of platelet aggregation Prostaglandins 19(4),605-627(1980).
2. Blair, I.A., Hensby, C.N., and MacDermot, J. Prostacyclin-dependent activation of adenylate cyclase in a neuronal somatic cell hybrid: Prostanoid structure-activity relationships Br. J. Pharmac. 69(3),519-525(1980).