Exifone is a nootropic indicated for the treatment of cognitive dysfunctions in geriatric
patients. Its reported clinical efficacy is ascribed to pharmacological activities including
activation of neuronal oxygen and glucose metabolism, free radical scavenging, and
indirect effects on serotonergic and dopaminergic pathways.
Exifone is a nootropic drug and cognitive enhancing agent. Exifone is a free radical scavenger shown to have protective effects againts Exifone has been shown to antagonize amnesias induced by benzodiazepines in mice.
Preparation by condensation of gallic acid with pyrogallol,
? in the presence of zinc chloride at 120° (good yield) or at 145° for 3 h (Nencki reaction);
? in the presence of zinc chloride and phosphorous oxychloride at 80° for 2 h, via Fries rearrangement.
ChEBI: (2,3,4-trihydroxyphenyl)-(3,4,5-trihydroxyphenyl)methanone is a member of benzophenones.
