Picramic acid should not be subjected to strong shock or heat, and is a dangerous fire risk. Picramic acid reacts with strong oxidizing agents. . Explodes if dried and exposed to heat, flame, friction or shock. Wetting greatly reduces this tendency. Treat as an explosive. Mixing with reducing agents, including hydrides, sulfides, nitrides, and alkali metals may lead to a vigorous reaction that culminates in a detonation. May explode in the presence of a base such as sodium hydroxide or potassium hydroxide, even in the presence of water or organic solvents. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. An amino acid (reacts as an acid with bases and as a base with acids).
