5-Thio-D-glucose

5-Thio-D-glucose (20408-97-3) is a potent competitive inhibitor of the cellular transport of glucose and glucose-mediated insulin release.1 May be used to induce a state of glucose deprivation in laboratory animals.2 Stimulates feeding in rat models.3 Induces Alzheimer-like changes in frontal cortex and hippocampus in rats.4 Elevates renal TGF-b1 at a dose that does not prevent streptozotocin diabetes in rats.5

5-Thio-D-glucose (cas# 20408-97-3) is a compound useful in organic synthesis.

[1] Z WANG  H G. Glucose transporter 2 expression: prevention of streptozotocin-induced reduction in beta-cells with 5-thio-D-glucose.[J]. Experimental and Clinical Endocrinology & Diabetes, 1995, 103 Suppl 2: 83-97. DOI:10.1055/s-0029-1211400
[2] MAITREYEE SHAH. Recurrent glucose deprivation leads to the preferential use of lactate by neurons in the ventromedial hypothalamus.[J]. American journal of physiology. Endocrinology and metabolism, 2019, 316 5: E948-E955. DOI:10.1152/ajpendo.00468.2018
[3] AI-JUN LI. Stimulation of feeding by three different glucose-sensing mechanisms requires hindbrain catecholamine neurons.[J]. American journal of physiology. Regulatory, integrative and comparative physiology, 2014, 306 4: R257-64. DOI:10.1152/ajpregu.00451.2013
[4] MELITA SALKOVIC-PETRISIC. Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway[J]. Journal of Neurochemistry, 2006, 96 4: 1005-1015. DOI:10.1111/j.1471-4159.2005.03637.x
[5] LANE P. 5-thio-D-glucose elevates renal transforming growth factor beta-1 at a dose that does not prevent streptozocine diabetes in rats.[J]. Endocrinology, 2000, 26 1: 3337-3342. DOI:10.1210/en.141.9.3337