Basic information Safety Related Supplier

BIS(METHYLTHIO)GLIOTOXIN

Basic information Safety Related Supplier
BIS(METHYLTHIO)GLIOTOXIN Basic information
BIS(METHYLTHIO)GLIOTOXIN Chemical Properties
  • Boiling point:669.6±55.0 °C(Predicted)
  • Density 1.49±0.1 g/cm3(Predicted)
  • storage temp. −20°C
  • form White solid.
  • pka12.69±0.60(Predicted)
Safety Information
  • Hazard Codes Xn
  • Risk Statements 20/21/22
  • Safety Statements 36
  • RIDADR 1544
  • HazardClass 6.1(b)
  • PackingGroup III
BIS(METHYLTHIO)GLIOTOXIN Usage And Synthesis
  • Enzyme inhibitorThis naturally occurring indole derivative (FW = 356.47 g/mol; CAS 74149- 38-5), also known as bis(methylthio)gliotoxin and dimethylgliotoxin, is a platelet-acivating factor (PAF) antagonist that inhibits PAF-induced platelet aggregation. The parent compound, gliotoxin is a dual inhibitor of famesyltransferase and geranylgeranyl-transferase. Bisdethiobis(methylthio)gliotoxin is a minor metabolite of Gliocladium deliquescens, Radiocarbon tracer experiments showed it is formed, apparently irreversibly, from gliotoxin. It has also been synthesized from gliotoxin by reduction and methylation. Bisdethio-bis(methylthio)gliotoxin also binds Cu+ and Ag+ ions.
BIS(METHYLTHIO)GLIOTOXIN(74149-38-5)Related Product Information
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