N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide

109-01-3

2653-16-9

1139453-98-7

General procedure for the synthesis of N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide from N-methylpiperazine and 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide: 1-methylpiperazine (7.2 mL, 65 mmol) and potassium carbonate (13.8 g, 100 mmol) were dissolved in acetone (200 mL) and subsequently 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide (11.4 g, 50 mmol) was added slowly. The reaction mixture was stirred at room temperature for 12 hours. After completion of the reaction, the precipitate was removed by filtration and the filtrate was rotary evaporated to remove the solvent. The residue was dissolved in ethyl acetate (50 mL × 3) and extracted with 20 mL of water. The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent to give 15 g of the target compound. LC-MS analysis showed m/z = 293 ([M+H]+).