ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈
ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈
英文名称:α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
CAS号:218136-59-5
分子式:C27H29N5
分子量:423.55
EINECS号:
Mol文件:218136-59-5.mol
ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈 用途与合成方法
SC-26196 是一种有效的,具有口服活性的 Delta6 去饱和酶 (D6D, FADS2) 抑制剂 (在大鼠肝微粒体中,IC50=0.2 µM)。具有抗炎活性。 SC-26196 是一种有效的,具有口服活性的 Delta6 去饱和酶 (D6D, FADS2) 抑制剂 (在大鼠肝微粒体中,IC50=0.2 µM)。具有抗炎活性。
IC50: 0.2 µM (Delta6 desaturase in a rat liver microsomal assay)
SC-26196 (200 nM) inhibits proliferation of peripheral blood mononuclear cells (PBMCs), but Not Jurkat Cells.
Cell Proliferation Assay
Cell Line: | PBMCs and Jurkat cells |
Concentration: | 200 nM |
Incubation Time: | 96 hours for PBMCs; 144 hours for Jurkat cells |
Result: |
Treatment of PBMCs significantly decreased the proportion of cells that underwent division, the division index and proliferation index.
Did not alter cell proliferation significantly in Jurkat cells. |
SC-26196 ( included in the diet at 0, 0.07, 0.21, or 0.7 mg/kg diet to achieve dosages of 0, 10, 30, and 100 mg/kg per day) causes a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver. Feeding 100 mg SC-26196 per kg BW per day inhibits the Δ6-desaturase enzyme.
Animal Model: | Male mice (12- or 15-week-old) |
Dosage: | 0, 10, 30, and 100 mg/kg per day |
Administration: | Included in the diet at 0, 0.07, 0.21, or 0.7mg/kg diet to achieve dosages of 0, 10, 30, and 100mg/kg per day. |
Result: | Caused a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver. |
ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024-11-08 | HY-107410 | 1 mg | 522 | ||
2024-11-08 | HY-107410 | ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈 | 218136-59-5 | 5mg | 1150 |
ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈供应商 更多
北京百灵威科技有限公司
联系电话:010-82848833 400-666-7788
产品介绍:
英文名称:SC-26196
CAS:218136-59-5
包装信息:100Mg,10Mg
备注:化学试剂、精细化学品、医药中间体、材料中间体
武汉易泰科技有限公司上海分公司
联系电话:821-50328103-801 18930552037
产品介绍:
中文名称:ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈
英文名称:SC 26196;α,α-Diphenyl-4-[(3-pyridinylMethylene)aMino]-1-piperazinepentanenitrile
CAS:218136-59-5
纯度:99% HPLC
包装信息:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
南京诺利斯医药科技有限公司
联系电话: 13901585132
产品介绍:
中文名称:ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈
英文名称:α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
CAS:218136-59-5
纯度:0.95
包装信息:5KG;1KG;100G
广州爱纯医药科技有限公司
联系电话:020-39119399 18927568969
产品介绍:
中文名称:ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈
英文名称:SC-26196
CAS:218136-59-5
纯度:98% (HPLC)
包装信息:5MG; 25MG; 100MG; 1G
备注:品牌:StdSun | 提供定制合成服务(包括:小分子,药物杂质及医药中间体)
南京恰风和医药科技有限公司
联系电话:025-57018978 18251899859
产品介绍:
中文名称:ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈
英文名称:(E)-2,2-diphenyl-5-(4-(pyridin-3-ylmethyleneamino)piperazin-1-yl)pentanenitrile
CAS:218136-59-5
纯度:97%
包装信息:500G;250g;100g;50g;25g
ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈生产厂家及价格列表
SC-26196
上海巢莱化工科技中心
2024-12-17
化合物 SC-26196|T12856|TargetMol
TargetMol中国(陶术生物)
2024-12-12