2-(1H-indol-3-yl)-2-methylpropan-1-amine

23078-29-7

15467-31-9

2-(1H-indol-3-yl)-2-methylpropionitrile (1.8 g, 9.8 mmol) was dissolved in tetrahydrofuran (4 mL) at 25 °C, followed by the addition of methanol (10 mL) and Ruanne nickel catalyst (200 mg). The reaction was carried out under hydrogen pressure of 2.2 MPa for 72 hours. Upon completion of the reaction, the reaction was stopped and filtration was performed. The filtrate was concentrated by rotary evaporation under reduced pressure and subsequently purified by column chromatography with an eluent ratio of dichloromethane/methanol (v/v) = 20/1, which ultimately afforded the target product 2-(1H-indol-3-yl)-2-methyl-1-propanamine as a light yellow oil (1.58 g, 86% yield).